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KMID : 0365819630030020385
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Journal of Pusan Medical College
1963 Volume.3 No. 2 p.385 ~ p.390
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The Effects of Various Intravenous Fluids on Cerebrospinal Fluid Pressure
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Abstract
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The effects of various intravenous solutions on cerebrospinal fluid pressure were studied in 112 adults with normal as well as increased intracranial pressure.
Intravenous infusion of 5 percent dextrose in water or 10 per cent dextrose in water or normal saline solution produced a moderate increase in the cerebrospinal fluid pressure.
Whole blood or protein hydrolysate solution or 6 per cent dextran solution produced more significant increase in the cerebrospinal fluid pressure.
By intravenous infusion of 50 per cent dextrose in water the cerebrospinal fluid pressure decreased markedly but in a short time (30 to.40minutes) increased steeply up to more than the initial pressure. Five per cent dextrose and 0.9 per cent saline solution or 3.5 per cent polyvinyl pyrolidone in normal saline solution or in Ringer´s solution reduced the cerebrospinal fluid pressure moderately and its effects is accelerated with caffein & sodium benzoate.
The effects of various intravenous solution are more active on an increased intracranial pressure than on normal one, and the increase or the decrease in the pressure is markedly correlated with the rate of infusion, it is being greter if the rate was above 10cc per minute.
Five per cent dextrose & 0. 9 per cent saline solution of 1000~2000cc or 3.5 per cent P. V. P. in normal saline solution of 200~400cc with 25 per cent caffein & sodium benzoate solution of 1~2cc added to the former solutions reduced the cerebrospinal fluid pressure down to below about 70 percent of the initial pressure for 3~4 hours.
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